BOTOX is FDA approved and has been safely used for over 10 years. BOTOX Cosmetic is used to relax muscles on the face. The most common places are between the eyebrows, around the eyes, and on the forehead. At times BOTOX Therapeutic is used for migraines and excess perspiration. Small needles are used to administer BOTOX so pain is minimal. It usually takes about 10 days to see the full effect of BOTOX.